"That feeling of annoyance sets off a stress response in your body that's very similar to the stress response you would have if you were walking down a dark alleyway, and out jumps a ferocious pitbull. It's your body telling itself to either prepare to fight that threat or flee that threat. [...] Consistent stimulation of that stress response can lead to increased risk for some pretty serious cardiovascular related illnesses like hypertension or cardiovascular related mortality."